ERA Testing for repeated failed pregnancies

Recurrent or repeated implantation failure (RIF) can be disheartening despite seemingly successful IVF cycles. Despite positive indicators such as a good number of eggs, healthy embryos, and a conducive uterine lining, achieving a successful pregnancy remains elusive.



ERA Testing for Repeated Failed Pregnancies

For both patients and reproductive specialists, discovering the cause of repeated implantation failure can be challenging. Fortunately, ongoing advancements like the ERA test offer renewed hope and insights into why implantation may fail. Seeking assistance from renowned IVF centres like World IVF Center in Delhi can be beneficial.

Factors Contributing to Implantation Failure

Implantation failure stems from genetic abnormalities in embryos or issues related to uterine receptivity. Genetic defects in embryos, especially in older women's eggs, are common causes, reducing the implantation rate with age. For cases of RIF, genetic testing like Preimplantation Genetic Screening (PGS) is often the initial approach. Additionally, examining embryos for chromosomal problems before implantation or using donor eggs can improve success rates.

Regarding uterine receptivity, several factors can contribute, such as physical uterus issues, hormonal imbalances, thyroid function, or problems with the endometrial lining. The ERA test serves as a valuable tool in evaluating the endometrial lining's readiness for embryo implantation.

Understanding the ERA Test

The Endometrial Receptivity Analysis (ERA) assesses a woman's endometrial tissue sample to ascertain its readiness to receive an implanting embryo. During the luteal phase of the menstrual cycle, progesterone initiates changes in the uterine lining to create an optimal environment for implantation.

The ERA test works by examining the expression of specific RNA types in the endometrial cells, which indicates receptivity. A database of endometrial tissue samples has been established to categorise samples as "Receptive" or "Non-Receptive" based on their RNA expression profiles. This helps determine the ideal window for embryo transfer synchronisation with the uterine lining.

Conducting the ERA Test

The procedure involves collecting a uterine lining sample at a precise cycle stage. Utilising fertility drugs to prepare the uterine lining, a biopsy is then performed to obtain the tissue sample. The sample is examined using advanced technology, and results are available within three weeks. If deemed "Non-Receptive," subsequent tests are conducted to identify the ideal transfer time.

For those facing recurrent implantation failure, ERA testing offers valuable insights, potentially leading to a successful outcome with a slight adjustment in embryo transfer timing. Consulting with a fertility specialist about ERA after multiple implantation failures can provide new strategies for achieving pregnancy success.

 

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